Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-65355394 is an effective O-GlcNAc hydrolase (OGA) inhibitor and an OGA chemical probe.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 465.00 | |
10 mg | In stock | $ 679.00 | |
25 mg | In stock | $ 1,070.00 | |
50 mg | In stock | $ 1,430.00 | |
100 mg | In stock | $ 1,930.00 |
Description | JNJ-65355394 is an effective O-GlcNAc hydrolase (OGA) inhibitor and an OGA chemical probe. |
Targets&IC50 | GPR139 (human):16 ± 6 nM(EC50), GTPγS:17 ± 4 Nm(EC50) |
In vitro | JNJ-63533054 induced luciferase activity against zebrafish GPR139 in a concentration-dependent manner. For zebrafish GPR139, the maximal induction of 3.3-fold of vehicle control was achieved at a concentration of 128nM. From the dose-response curve, the half effective maximal concentration (EC50) values of JNJ-63533054 to zebrafish GPR139 was 3.91nM.[1] |
In vivo |
JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM). [2] JNJ-63533054 crosses the rat blood-brain barrier after oral administration and achieves exposure in the micromolar range. JNJ-63533054 administration decreases spontaneous locomotor activity in rats.[2] |
Molecular Weight | 358.5 |
Formula | C19H26N4OS |
CAS No. | 2230598-99-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (83.68 mM)
You can also refer to dose conversion for different animals. More
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JNJ-65355394 2230598-99-7 Others JNJ65355394 JNJ 65355394 inhibitor inhibit