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SLM6031434 HCl

Name: SLM6031434 HCl
Brand: TargetMol
SKU: T28806
Rating: 4.5 (1 reviews)

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Catalog No. T28806Cas No. 1897379-34-8

Alias SLM-6031434 HCl, SLM 6031434 HCl

SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.

SLM6031434 HCl

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Catalog No. T28806Alias SLM-6031434 HCl, SLM 6031434 HClCas No. 1897379-34-8

SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$185	35 days	35 days
5 mg	$593	35 days	35 days
10 mg	$833	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.
In vitro	b>METHODS: U937 cells exposed to 1 μM FTY720 were treated with concentrations of SLM6031434 HCl (0.1, 0.3 μM, 2 hours), harvested by centrifugation and processed for LC/MS. RESULTS: SLM6031434 HCl blocked FTY720 phosphorylation in cultured U937 cells. [1]
In vivo	b>METHODS: SLM6031434 HCl (10 mg/kg, intraperitoneal injection) was administered to mice lacking a functional SphK1 allele (Sphk1−/−) /SphK2 deficient (Sphk2−/−) and whole blood was processed for LC/MS analysis. RESULTS: Administration of SLM6031434 HCl to mice lacking a functional SphK1 allele (Sphk1−/−) resulted in a decrease in blood S1P; SLM6031434 HCl did not affect blood S1P concentrations in SphK2 deficient (Sphk2−/−) mice. [1]
Synonyms	SLM-6031434 HCl, SLM 6031434 HCl

Chemical Properties

Molecular Weight	489.96
Formula	C₂₂H₃₁ClF₃N₅O₂
Cas No.	1897379-34-8
Smiles	C(=N)(N)N1[C@@H](CCC1)C2=NC(=NO2)C3=CC(C(F)(F)F)=C(OCCCCCCCC)C=C3.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (61.23 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0410 mL	10.2049 mL	20.4098 mL	102.0491 mL
5 mM	0.4082 mL	2.0410 mL	4.0820 mL	20.4098 mL
10 mM	0.2041 mL	1.0205 mL	2.0410 mL	10.2049 mL
20 mM	0.1020 mL	0.5102 mL	1.0205 mL	5.1025 mL
50 mM	0.0408 mL	0.2041 mL	0.4082 mL	2.0410 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc