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type II collagen fragment

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Catalog No. TP2301

Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), maybe a critical event in the pathology of many arthritides, due in part to the very slow rate of collagen turnover within the cartilage2.

type II collagen fragment

type II collagen fragment

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Catalog No. TP2301
Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), maybe a critical event in the pathology of many arthritides, due in part to the very slow rate of collagen turnover within the cartilage2.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$50InquiryInquiry
5 mg$143InquiryInquiry
10 mg$235InquiryInquiry
25 mg$329InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), maybe a critical event in the pathology of many arthritides, due in part to the very slow rate of collagen turnover within the cartilage2.
In vitro
Type II collagen and aggrecan (a large, aggregating proteoglycan) are the two major components of the extracellular matrix of cartilage. The collagen, which is present in a fibrillar form, provides tensile strength whereas the aggrecan is responsible for compressive stiffness of cartilage3-5. Early damage to type II collagen is predominantly pericellular/ territorial suggests that in the majority of cases collagen damage was mediated by the chondrocyte.
Chemical Properties
Molecular Weight1471.61
FormulaC65H102N18O21
SmilesNCC(NC(CCC(O)=O)C(N1CCCC1C(NCC(NC(C(C)CC)C(NC(C)C(NCC(NC(CC2=CC=CC=C2)C(NC(CCCCN)C(NCC(NC(CCC(O)=O)C(NC(CCC(N)=O)C(NCC(N3C(C(NC(CCCCN)C(O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Relative Density.1.31g/cm3
SequencePro-Thr-Gly-Pro-Leu-Gly-Pro-Lys-Gly-Gln-Thr-Gly-Glu-Leu-Gly-Ala-{Hyp}-Gly-Asn-Lys-Gly-Glu-Gln-Gly-Pro-Lys
Sequence ShortPTGPLGPKGQTGELGA-{Hyp}-GNKGEQGPK
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥147.1 mg/mL, Sonication is recommended.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

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All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
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Keywords

type II collagen fragment
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