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Anti-IL-18R alpha Antibody (9P457)
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Catalog No. TMAY-01645
Alias interleukin 18 receptor 1, IL-1Rrp, IL1RRP, IL18RA, CDw218a, CD218a
Anti-IL-18R alpha Antibody (9P457) is a Mouse antibody targeting IL-18R alpha. Anti-IL-18R alpha Antibody (9P457) can be used in FCM.
Anti-IL-18R alpha Antibody (9P457)
Anti-IL-18R alpha Antibody (9P457)
😃Good
Catalog No. TMAY-01645Alias interleukin 18 receptor 1, IL-1Rrp, IL1RRP, IL18RA, CDw218a, CD218a
Anti-IL-18R alpha Antibody (9P457) is a Mouse antibody targeting IL-18R alpha. Anti-IL-18R alpha Antibody (9P457) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | interleukin 18 receptor 1, IL-1Rrp, IL1RRP, IL18RA, CDw218a, CD218a |
| Ig Type | Mouse IgG2a |
| Clone | 9P457 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human IL18R1(CD218a) expression on human whole blood granulocytes. Cells were stained with purified anti-Human IL18R1(CD218a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18R1 (rh IL18R1; TMPY-01219; NP_003846.1; Met1-Arg329). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause. |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human IL18R1 Protein (TMPY-01219) |
| Antigen Species | Human |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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