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Anti-PBK/TOPK Antibody (4O108)
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Catalog No. TMAY-01108
Alias TOPK, SPK, PDZ binding kinase, Nori-3, HEL164, CT84
Anti-PBK/TOPK Antibody (4O108) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (4O108) can be used in WB,ELISA,ELISA(Det).
Anti-PBK/TOPK Antibody (4O108)
Anti-PBK/TOPK Antibody (4O108)
😃Good
Catalog No. TMAY-01108Alias TOPK, SPK, PDZ binding kinase, Nori-3, HEL164, CT84
Anti-PBK/TOPK Antibody (4O108) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (4O108) can be used in WB,ELISA,ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | 66 € | 7-10 days | |
| 100 μL | 188 € | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PBK/TOPK Antibody (4O108) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (4O108) can be used in WB,ELISA,ELISA(Det). |
| Alias | TOPK, SPK, PDZ binding kinase, Nori-3, HEL164, CT84 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4O108 |
| Reactivity | Human |
| Verified Activity | Anti-PBK mouse monoclonal antibody at 1:500 dilution. -Lane A: SW480 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:36 kDa. -Observed band size:38 kDa |
| Application | WB,ELISA,ELISA(Det) |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:5000-1:10000; ELISA(Det): 1:5000-1:50000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PBK / TOPK (rh PBK; TMPY-04547; NP_060962.2; Met 1-Val 322). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human PBK protein (TMPY-04547) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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