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ARD-2585

Name: ARD-2585
Brand: TargetMol
SKU: T74141
Rating: 4.5 (1 reviews)

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Catalog No. T74141Cas No. 2757422-79-8

Alias ARD2585

ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.

ARD-2585

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Catalog No. T74141Alias ARD2585Cas No. 2757422-79-8

ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$333	Inquiry	Inquiry
5 mg	$795	Inquiry	Inquiry
10 mg	$1,280	Inquiry	Inquiry
25 mg	$2,530	Inquiry	Inquiry
50 mg	$3,970	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.
Targets&IC50	LNCaP AR+ cell:16.2 nM, VCaP cells:1.5 nM
In vitro	ARD-2585 is effective in reducing the AR protein level at the 3 and 24 h time-points by 78% and 60% at the 6 h time-point. ARD-2585 achieves picomolar DC50 values and >98% of Dmax in the VCaP cell line with a wild-type AR and in the LNCaP cell line carrying a T878A-mutated AR mutant. ARD-2585 potently inhibits cell growth with IC50 values of 1.5 nM and 16.2 nM in the VCaP and LNCaP AR+ prostate cancer cell lines. [1]
In vivo	At the end of the treatment (day 37), 20 and 40 mg/kg ARD-2585 inhibits tumor growth by 54.9, 74.3, and 65.9%. ARD-2585 effectively reduces AR protein the VCaP xenograft tumor tissue in mice and inhibits VCaP tumor growth. [1]
Synonyms	ARD2585

Chemical Properties

Molecular Weight	763.28
Formula	C₄₁H₄₃ClN₈O₅
Cas No.	2757422-79-8
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=C(C2)N4CC(C4)N5CCN(CC5)C6=CC=C(C(N[C@H]7CC[C@H](N(C)C8=CC(Cl)=C(C#N)C=C8)CC7)=O)C=C6

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (104.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 5 mg/mL (6.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3101 mL	6.5507 mL	13.1014 mL	65.5068 mL
5 mM	0.2620 mL	1.3101 mL	2.6203 mL	13.1014 mL
10 mM	0.1310 mL	0.6551 mL	1.3101 mL	6.5507 mL
20 mM	0.0655 mL	0.3275 mL	0.6551 mL	3.2753 mL
50 mM	0.0262 mL	0.1310 mL	0.2620 mL	1.3101 mL
100 mM	0.0131 mL	0.0655 mL	0.1310 mL	0.6551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc