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Syringic acid

Name: Syringic acid
Brand: TargetMol
SKU: T2883
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2883Cas No. 530-57-4

Alias SYRA, NSC 2129, 3,5-dimethyl ether Gallic Acid, 3,5-dimethoxy-4-hydroxy Benzoic Acid

Syringic acid (3,5-dimethoxy-4-hydroxy Benzoic Acid) (SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.

Syringic acid

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Purity: 99.29%

Catalog No. T2883Alias SYRA, NSC 2129, 3,5-dimethyl ether Gallic Acid, 3,5-dimethoxy-4-hydroxy Benzoic AcidCas No. 530-57-4

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$73	-	In Stock
1 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.29%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Syringic acid AI Summary

Syringic acid exhibits a diverse range of bioactivities. It shows antioxidant properties with DPPH radical scavenging IC50 values of 7400.0 nM and 7300.0 nM in liposome and ethanol solution assays, respectively, and EC50 value of 42.7 nM. Additionally, it demonstrates significant inhibition against various carbonic anhydrase isoforms (Ki values 3190.0 nM to 35400.0 nM). Its antitubercular activity is noted against Mycobacterium tuberculosis strain 90-221387 with an MIC of 318000.0 nM. Syringic acid also possesses antiplatelet activity, significantly inhibiting thrombin, arachidonic acid, collagen, and platelet-activating factor-induced aggregations at 100 µg/mL. It shows moderate antifungal activity against several fungal strains with growth inhibition ranging from 14.0% to 24.0%. The compound demonstrates weak inhibition of bovine thymocyte protein tyrosine kinase with an IC50 over 500.0 µg/mL and low inhibition of mushroom tyrosinase (2.4% inhibition, IC50 >100000 nM). It also exhibits antiviral activity against SARS-CoV-2 (IC50 >20000 nM), antifeedant activity against Hylobius abietis (AFI 8.0% at 50 mM), and inhibition of Lasiodiplodia theobromae ligninolytic enzymes (58.0% and 57.0% inhibition of laccase and pectinase activities, respectively). Furthermore, it induces nerve growth factor secretion in rat C6 cells (125.5% of control at 20 µM), shows cytotoxicity against various cancer cell lines with IC50 >10000 nM, and inhibits PKM2 with an IC50 of 13800.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Syringic acid (3,5-dimethoxy-4-hydroxy Benzoic Acid) (SYRA) is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic, neuroprotective, and memory-enhancing properties.
Synonyms	SYRA, NSC 2129, 3,5-dimethyl ether Gallic Acid, 3,5-dimethoxy-4-hydroxy Benzoic Acid

Chemical Properties

Molecular Weight	198.17
Formula	C₉H₁₀O₅
Cas No.	530-57-4
Smiles	O(C)C1=C(O)C(OC)=CC(C(O)=O)=C1
Relative Density.	1.2539 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247 mg/mL (1246.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (25.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0462 mL	25.2309 mL	50.4617 mL	252.3086 mL
5 mM	1.0092 mL	5.0462 mL	10.0923 mL	50.4617 mL
10 mM	0.5046 mL	2.5231 mL	5.0462 mL	25.2309 mL
20 mM	0.2523 mL	1.2615 mL	2.5231 mL	12.6154 mL
50 mM	0.1009 mL	0.5046 mL	1.0092 mL	5.0462 mL
100 mM	0.0505 mL	0.2523 mL	0.5046 mL	2.5231 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc