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Ropidoxuridine

Name: Ropidoxuridine
Brand: TargetMol
SKU: T16785
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16785Cas No. 93265-81-7

Alias IPdR

Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) prodrug.

Ropidoxuridine

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Purity: 97.07%

Catalog No. T16785Alias IPdRCas No. 93265-81-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$103	In Stock	In Stock
10 mg	$167	In Stock	In Stock
25 mg	$279	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$538	In Stock	In Stock
200 mg	$691	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.07%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) prodrug.
In vitro	Ropidoxuridine is an orally bioavailable prodrug of IUdR. Ropidoxuridine shows strong synergy effects with Alisertib at clinically relevant concentrations.[1]
In vivo	Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) has strong synergy effects, in an orthotopic tumor model.[1]
Synonyms	IPdR

Chemical Properties

Molecular Weight	338.1
Formula	C₉H₁₁IN₂O₄
Cas No.	93265-81-7
Smiles	OC[C@H]1O[C@H](C[C@@H]1O)n1cc(I)cnc1=O
Relative Density.	2.22g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (665.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (9.76 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9577 mL	14.7885 mL	29.5770 mL	147.8852 mL
5 mM	0.5915 mL	2.9577 mL	5.9154 mL	29.5770 mL
10 mM	0.2958 mL	1.4789 mL	2.9577 mL	14.7885 mL
20 mM	0.1479 mL	0.7394 mL	1.4789 mL	7.3943 mL
50 mM	0.0592 mL	0.2958 mL	0.5915 mL	2.9577 mL
100 mM	0.0296 mL	0.1479 mL	0.2958 mL	1.4789 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc