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Ropidoxuridine

Name: Ropidoxuridine
Brand: TargetMol
SKU: T16785
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16785Cas No. 93265-81-7

Alias IPdR

Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) prodrug.

Ropidoxuridine

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Purity: 97.07%

Catalog No. T16785Alias IPdRCas No. 93265-81-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$103	In Stock	In Stock
10 mg	$167	In Stock	In Stock
25 mg	$279	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$538	In Stock	In Stock
200 mg	$691	-	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.07%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ropidoxuridine (IPdR) is a novel, orally available halogenated thymidine analogue that holds promise as a sensitizer for human tumors.Ropidoxuridine is an orally available and bioavailable IUdR (5-iodo-2'-deoxyuridine) prodrug.
In vitro	Ropidoxuridine is an orally bioavailable prodrug of IUdR. Ropidoxuridine shows strong synergy effects with Alisertib at clinically relevant concentrations.[1]
In vivo	Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) has strong synergy effects, in an orthotopic tumor model.[1]
Synonyms	IPdR

Chemical Properties

Molecular Weight	338.1
Formula	C₉H₁₁IN₂O₄
Cas No.	93265-81-7
Smiles	OC[C@H]1O[C@H](C[C@@H]1O)n1cc(I)cnc1=O
Relative Density.	2.22g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (665.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (9.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9577 mL	14.7885 mL	29.5770 mL	147.8852 mL
5 mM	0.5915 mL	2.9577 mL	5.9154 mL	29.5770 mL
10 mM	0.2958 mL	1.4789 mL	2.9577 mL	14.7885 mL
20 mM	0.1479 mL	0.7394 mL	1.4789 mL	7.3943 mL
50 mM	0.0592 mL	0.2958 mL	0.5915 mL	2.9577 mL
100 mM	0.0296 mL	0.1479 mL	0.2958 mL	1.4789 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc