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Su1498
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Catalog No. T3980Cas No. 168835-82-3
Alias Tyrphostin SU 1498, AG 1498
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
Su1498
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Purity: 99.89%
Catalog No. T3980Alias Tyrphostin SU 1498, AG 1498Cas No. 168835-82-3
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $34 | In Stock | In Stock | |
| 2 mg | $47 | In Stock | In Stock | |
| 5 mg | $72 | In Stock | In Stock | |
| 10 mg | $122 | In Stock | In Stock | |
| 25 mg | $233 | In Stock | In Stock | |
| 50 mg | $346 | In Stock | In Stock | |
| 100 mg | $513 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $79 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
Su1498 AI Summary
Su1498 is a potent inhibitor of VEGFR2 with an IC50 value of 700.0 nM. It also exhibits a broad range of bioactivities by stabilizing a variety of protein targets involved in crucial cellular signaling pathways, including but not limited to AMPKA2, CAMK family (1D, 1G, 2A, 2B, 2D, 2G, 4), CAMKK2, CDK family (2, 6, L1), CHEK2, CLK family (1, 2, 3), CK1G family (1, 2, 3), DAPK3, DMPK1, GSK3B, JAK1, MEK2, MAP2K6, ASK1, p38beta, ERK family (1, 3), MST4, NEK family (2, 6), OSR1, PAK family (4, 5, 6), PCTK1, PDK1, PIM family (1, 2, 3), PLK family (1, 4), PRKACA, RIOK2, RSK2a, RSK2b, SLK, LOK, MPSK1, DRAK1, NDR1, MST1, TNIK, PBK, VRK family (1, 2, 3), and YSK1. The compound induces thermal melting changes in these proteins, indicating a significant impact on their stability and function.
In various assay screenings, Su1498 shows additional bioactivities:
- Enhances SMN2 splice variant expression with a potency of 28183.8 nM.
- Inhibits tau fibril formation with a potency of 11220.2 nM.
- Acts as a cell-membrane-permeable IMPase inhibitor in conjunction with lithium, with a potency of 5011.9 nM.
- Inhibits human tyrosyl-DNA phosphodiesterase 1, both with and without CPT in cells, with a potency of 20596.2 nM.
- Inhibits binding or entry into cells for Lassa Virus with a potency of 25118.9 nM and for Marburg Virus with a potency of 35481.3 nM.
- Exhibits antiviral activity against Foot and Mouth Disease Virus with a potency of 28183.8 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration. |
| Targets&IC50 | VEGFR2:700 nM |
| Synonyms | Tyrphostin SU 1498, AG 1498 |
| Molecular Weight | 390.52 |
| Formula | C25H30N2O2 |
| Cas No. | 168835-82-3 |
| Smiles | CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O |
| Relative Density. | 1.100 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (384.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.24 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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