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RDR03871

🥰Excellent
Catalog No. T28509Cas No. 286008-51-3
Alias ZINC20458540, RDR-03871, RDR 03871

RDR03871 is an MDM2 inhibitor.

RDR03871

RDR03871

🥰Excellent
Purity: 97.78%
Catalog No. T28509Alias ZINC20458540, RDR-03871, RDR 03871Cas No. 286008-51-3
RDR03871 is an MDM2 inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$70In StockIn Stock
5 mg$161In StockIn Stock
10 mg$236In StockIn Stock
25 mg$355In StockIn Stock
50 mg$497In StockIn Stock
100 mg$678In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:97.78%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
RDR03871 is an MDM2 inhibitor.
In vitro
RDR03871 dissociated the MDM2/p53 with IC50 of 12.9nM in quantitative sandwich immune-enzymatic assays.
SynonymsZINC20458540, RDR-03871, RDR 03871
Chemical Properties
Molecular Weight408.81
FormulaC18H16ClF3N6
Cas No.286008-51-3
SmilesN(CCNC=1N=C(C(F)(F)F)C=CC1)C2=NC(=NC(C)=C2Cl)C3=CC=CC=N3
Relative Density.1.413 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.09 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4461 mL12.2306 mL24.4612 mL122.3062 mL
5 mM0.4892 mL2.4461 mL4.8922 mL24.4612 mL
10 mM0.2446 mL1.2231 mL2.4461 mL12.2306 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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