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SIRT-IN-2

🥰Excellent
Catalog No. T12919Cas No. 1431411-66-3

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor [IC50s of 4, 1, and 7 μM, respectively].

SIRT-IN-2

SIRT-IN-2

🥰Excellent
Purity: 98.26%
Catalog No. T12919Cas No. 1431411-66-3
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor [IC50s of 4, 1, and 7 μM, respectively].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$98In StockIn Stock
5 mg$239In StockIn Stock
10 mg$383In StockIn Stock
25 mg$653In StockIn Stock
50 mg$893In StockIn Stock
100 mg$1,220In StockIn Stock
200 mg$1,630-In Stock
1 mL x 10 mM (in DMSO)$263In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.26%
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Product Introduction

Bioactivity
Description
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor [IC50s of 4, 1, and 7 μM, respectively].
Targets&IC50
SIRT2:1 nM, SIRT1:4 nM, SIRT3:7 nM
In vitro
SIRT-IN-2 is one of the most potent truncated pan SIRT1/ 2/3 inhibitor(IC50 values are 4, 4, 7 μM, respectively). SIRT-IN-2 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.
Chemical Properties
Molecular Weight383.49
FormulaC15H21N5O3S2
Cas No.1431411-66-3
SmilesCS(=O)(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 62.5 mg/mL (162.98 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 2.5 mg/mL (6.52 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6076 mL13.0381 mL26.0763 mL130.3815 mL
5 mM0.5215 mL2.6076 mL5.2153 mL26.0763 mL
10 mM0.2608 mL1.3038 mL2.6076 mL13.0381 mL
20 mM0.1304 mL0.6519 mL1.3038 mL6.5191 mL
50 mM0.0522 mL0.2608 mL0.5215 mL2.6076 mL
100 mM0.0261 mL0.1304 mL0.2608 mL1.3038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SirtuinSIRT-IN-2SIRTIN2SIRT3SIRT2SIRT1SIRT IN 2Inhibitorinhibit
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