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SGK

Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (compare Treefam family TF320906). In most vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to the first cloning of a SGK family member from a cDNA library screen for genes upregulated by the glucocorticoid dexamethasone in a rat mammary epithelial tumor cell line. The first human family member (human SGK1) was cloned in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.

  • Ro-3306
    T2356872573-93-8
    RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.
    • $32
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    TargetMol | Citations Cited
  • EMD638683 R-Form
    T111811184940-47-3
    EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
    • $193
    5 days
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  • PROTAC SGK3 degrader-1
    T138472381320-35-8
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of cancer cells.CAS 번호5017-88-83-4
    • $479
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    TargetMol | Inhibitor Sale
  • SGK1-IN-4
    T99771628048-93-0
    SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.
    • $113
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  • AT13148
    T24821056901-62-2
    AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
    • $41
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  • BRD7389
    T14779376382-11-5
    BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
    • $77
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  • CKI-7
    T199131177141-67-1
    CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
    • $193
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  • EMD638683
    T66351181770-72-8
    EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).
    • $89
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  • SI-113
    T95891392816-46-4
    SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
    • $38
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  • URMC-099
    T60571229582-33-5
    URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
    • $52
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  • GSK 650394
    T2622890842-28-1
    GSK 650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.
    • $34
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