Shopping Cart

Your shopping cart is currently empty

Cobimetinib hemifumarate (Synonyms: XL-518 hemifumarate, XL518 hemifumarate, XL 518 hemifumarate, GDC-0973 he...)

Name: Cobimetinib hemifumarate
Brand: TargetMol
SKU: T64175
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T64175 Copy Product Info

🥰Excellent

Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.

Cobimetinib hemifumarate

Copy Product Info

🥰Excellent

Catalog No. T64175

Synonyms XL-518 hemifumarate, XL518 hemifumarate, XL 518 hemifumarate, GDC-0973 hemifumarate, GDC0973 hemifumarate, GDC 0973 hemifumarate

Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.

Cas No. 1369665-02-0

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$37	-	In Stock
5 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1.
Targets&IC50	MEK1:4.2 nM
In vitro	The EC50 values of Cobimetinib hemifumarate(GDC-0973) on 888MEL and A2058 cells were 0.2 μM and 10 μM, respectively. Melanoma cells were treated with MEK and PI3K inhibitors with EC50 concentration for 24 hours (888mel: 0.05μ m GDC-0973, 2.5 μM GDC-0941；; A2058：2.5 μM GDC-0973、2.5 μM GDC-0941）[1]。 Mitochondrial oxidative phosphorylation can limit cell death induced by Cobimetinib hemifumarate(100 nM) in melanoma with constitutive MAPK activation in A375 cells [4].
Synonyms	XL-518 hemifumarate, XL518 hemifumarate, XL 518 hemifumarate, GDC-0973 hemifumarate, GDC0973 hemifumarate, GDC 0973 hemifumarate

Chemical Properties

Molecular Weight	1178.71
Formula	C₄₆H₄₆F₆I₂N₆O₈
Cas No.	1369665-02-0
Smiles	OC(=O)\C=C\C(O)=O.OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1.OC1(CN(C1)C(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F)[C@@H]1CCCCN1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (42.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8484 mL	4.2419 mL	8.4839 mL	42.4193 mL
5 mM	0.1697 mL	0.8484 mL	1.6968 mL	8.4839 mL
10 mM	0.0848 mL	0.4242 mL	0.8484 mL	4.2419 mL
20 mM	0.0424 mL	0.2121 mL	0.4242 mL	2.1210 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc