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Anti-Beclin 1 Antibody (4E564)
😃Good
Catalog No. TMAB-03081
Anti-Beclin 1 Antibody (4E564) is a Rabbit antibody targeting Beclin 1. Anti-Beclin 1 Antibody (4E564) can be used in IHC-P,WB,IF,IHC-Fr.
Anti-Beclin 1 Antibody (4E564)
Anti-Beclin 1 Antibody (4E564)
😃Good
Catalog No. TMAB-03081
Anti-Beclin 1 Antibody (4E564) is a Rabbit antibody targeting Beclin 1. Anti-Beclin 1 Antibody (4E564) can be used in IHC-P,WB,IF,IHC-Fr.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 μg | $1,059 | 7-10 days | 7-10 days | |
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days | |
| 200 μL | $756 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Beclin 1 Antibody (4E564) is a Rabbit antibody targeting Beclin 1. Anti-Beclin 1 Antibody (4E564) can be used in IHC-P,WB,IF,IHC-Fr. |
| Ig Type | IgG |
| Clone | 4E564 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; WB: 1:200-1000; IF: 1:50-200; IHC-Fr: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. |
| Tissue Specificity | Ubiquitous. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. |
| Immunogen | Recombinant Protein: human Beclin 1 protein |
| Antigen Species | Human |
| Gene Name | BECN1 |
| Gene ID | |
| Protein Name | Beclin-1 |
| Uniprot ID | |
| Function | Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. |
| Molecular Weight | Theoretical: 50 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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