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ERAP1-IN-1

🥰Excellent
Catalog No. T11221Cas No. 865273-97-8

ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor that allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates, while competitively inhibiting its activity toward a nonamer peptide representative of physiological substrates.

ERAP1-IN-1

ERAP1-IN-1

🥰Excellent
Purity: 98.95%
Catalog No. T11221Cas No. 865273-97-8
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor that allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates, while competitively inhibiting its activity toward a nonamer peptide representative of physiological substrates.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$79In StockIn Stock
5 mg$173In StockIn Stock
10 mg$287In StockIn Stock
25 mg$473In StockIn Stock
50 mg$648In StockIn Stock
100 mg$888In StockIn Stock
200 mg$1,190-In Stock
1 mL x 10 mM (in DMSO)$173In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.95%
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Product Introduction

Bioactivity
Description
ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor that allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substrates, while competitively inhibiting its activity toward a nonamer peptide representative of physiological substrates.
In vitro
ERAP1-IN-1 (50 μM) exhibits specific inhibition of ERAP1 in the cellular context. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates.
Chemical Properties
Molecular Weight458.45
FormulaC20H21F3N2O5S
Cas No.865273-97-8
SmilesCOc1ccc(cc1S(=O)(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F)C(O)=O
Relative Density.1.428 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 250 mg/mL (545.32 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1813 mL10.9063 mL21.8126 mL109.0631 mL
5 mM0.4363 mL2.1813 mL4.3625 mL21.8126 mL
10 mM0.2181 mL1.0906 mL2.1813 mL10.9063 mL
20 mM0.1091 mL0.5453 mL1.0906 mL5.4532 mL
50 mM0.0436 mL0.2181 mL0.4363 mL2.1813 mL
100 mM0.0218 mL0.1091 mL0.2181 mL1.0906 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

reticulumInhibitorinhibitERAP1-IN-1ERAP-1-IN-1ERAP1IN1ERAP1 IN 1ERAP1endoplasmicaminopeptidase
Related Tags: buy ERAP1-IN-1 | purchase ERAP1-IN-1 | ERAP1-IN-1 cost | order ERAP1-IN-1 | ERAP1-IN-1 chemical structure | ERAP1-IN-1 in vitro | ERAP1-IN-1 formula | ERAP1-IN-1 molecular weight
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