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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $45 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Thymidine (DThyd) is a cell synchronizing agent and a specific precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis and can cause cell cycle arrest in the G1/S phase. |
In vitro | METHODS: Human hepatocellular carcinoma cells HepG2 were treated with Thymidine (300-1200 µM) and H2O2 (1 mM) for 0.5 h. DNA damage was detected by comet assay. RESULTS: For the control and Thymidine alone groups, the samples appeared almost circular due to the absence of DNA damage. After exposure to 1.0 mM H2O2 for 0.5 h, a clear comet was observed, indicating DNA damage in this group. However, there was a decreasing trend in the extent of DNA damage in the three combination groups as the concentration of Thymidine pretreatment increased. [1] METHODS: Jurkat, MOLT4 and NALM6 cells were treated with Thymidine (2 mM) for 18 h. RESULTS: Thymidine arrests the cell cycle at the G1/S boundary. [2] |
In vivo | METHODS: To investigate the effects of folate analogs on superantigen-reactive peripheral T cells in vivo, Thymidine (500 mg/kg) was injected intraperitoneally into MTX- or tomudex-administered mice twice daily for ten days. RESULTS: Both MTX and tomudex blocked the expansion and accelerated the peripheral clearance of Vβ8-selective T cells. Thymidine administration completely eliminated this effect, suggesting that inhibition of glycoside synthase (TS), but not other folate-dependent enzymes, is the predominant mechanism. [3] |
Alias | 5-Methyldeoxyuridine, Deoxyribothymidine, DThyd, NSC 21548, Thymidin |
Molecular Weight | 242.23 |
Formula | C10H14N2O5 |
Cas No. | 50-89-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Saline: 25 mg/mL (103.21 mM) Ethanol: Soluble DMSO: 50 mg/mL (206.42 mM) Pyridine, Methanol, etc.: Soluble | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Saline/DMSO
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