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Anti-CREB Antibody (1B178)
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Catalog No. TMAB-04647
Anti-CREB Antibody (1B178) is a Rabbit antibody targeting CREB. Anti-CREB Antibody (1B178) can be used in WB,IHC-P,IF,IHC-Fr.
Anti-CREB Antibody (1B178)
Anti-CREB Antibody (1B178)
😃Good
Catalog No. TMAB-04647
Anti-CREB Antibody (1B178) is a Rabbit antibody targeting CREB. Anti-CREB Antibody (1B178) can be used in WB,IHC-P,IF,IHC-Fr.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CREB Antibody (1B178) is a Rabbit antibody targeting CREB. Anti-CREB Antibody (1B178) can be used in WB,IHC-P,IF,IHC-Fr. |
| Ig Type | IgG |
| Clone | 1B178 |
| Reactivity | Human,Mouse (predicted:Rat) |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC-P: 1:50-200; IF: 1:50-200; IHC-Fr: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | pH7.4, 150mM NaCl, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein), which may reprecent a CREB co-activator. |
| Immunogen | KLH conjugated synthetic peptide: human CREB |
| Antigen Species | Human |
| Gene Name | CREB1 |
| Gene ID | |
| Protein Name | Cyclic AMP-responsive element-binding protein 1 |
| Uniprot ID | |
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. |
| Molecular Weight | Theoretical: 37 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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