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MB-07811

Name: MB-07811
Brand: TargetMol
SKU: T16018
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16018Cas No. 852948-13-1

Alias VK-2809

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB-07344, known for its cholesterol and triglycerides lowering activity and its function as a liver-targeted THR-β agonist.

MB-07811

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Purity: 99.94%

Catalog No. T16018Alias VK-2809Cas No. 852948-13-1

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB-07344, known for its cholesterol and triglycerides lowering activity and its function as a liver-targeted THR-β agonist.

Pack Size	Price	Availability
1 mg	$95	In Stock
5 mg	$262	In Stock
10 mg	$371	In Stock
25 mg	$592	In Stock
50 mg	$798	In Stock

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Batch Information

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Purity:99.94%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB-07344, known for its cholesterol and triglycerides lowering activity and its function as a liver-targeted THR-β agonist.
In vitro	MB-07811 has a low affinity for thyroid hormone receptors with a Ki of 14.6 μM for TRβ and a Ki of 12.5 μM for TRα[2].
In vivo	In diet-induced obese mice, MB-07811 (0.3-30 mg/kg) decreases cholesterol and triglycerides[2].
Synonyms	VK-2809

Chemical Properties

Molecular Weight	514.98
Formula	C₂₈H₃₂ClO₅P
Cas No.	852948-13-1
Smiles	C(OC1=CC(C)=C(CC2=CC(C(C)C)=C(O)C=C2)C(C)=C1)P3(=O)O[C@@H](CCO3)C4=CC(Cl)=CC=C4
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (87.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9418 mL	9.7091 mL	19.4182 mL	97.0911 mL
5 mM	0.3884 mL	1.9418 mL	3.8836 mL	19.4182 mL
10 mM	0.1942 mL	0.9709 mL	1.9418 mL	9.7091 mL
20 mM	0.0971 mL	0.4855 mL	0.9709 mL	4.8546 mL
50 mM	0.0388 mL	0.1942 mL	0.3884 mL	1.9418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc