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Werner syndrome RecQ helicase-IN-4

🥰Excellent
Catalog No. T72110Cas No. 2869954-53-8

Werner syndrome RecQ helicase-IN-4 is an effective inhibitor of Werner syndrome RecQ DNA helicase (WRN), exhibiting anticancer and antiproliferative activities, used for colorectal and gastric cancer research.

Werner syndrome RecQ helicase-IN-4

Werner syndrome RecQ helicase-IN-4

🥰Excellent
Purity: 98.27%
Catalog No. T72110Cas No. 2869954-53-8
Werner syndrome RecQ helicase-IN-4 is an effective inhibitor of Werner syndrome RecQ DNA helicase (WRN), exhibiting anticancer and antiproliferative activities, used for colorectal and gastric cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$132-In Stock
5 mg$328-In Stock
10 mg$529-In Stock
25 mg$953-In Stock
50 mg$1,490-In Stock
100 mg$1,970-In Stock
200 mg$2,690-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.27%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Werner syndrome RecQ helicase-IN-4 is an effective inhibitor of Werner syndrome RecQ DNA helicase (WRN), exhibiting anticancer and antiproliferative activities, used for colorectal and gastric cancer research.
Targets&IC50
WRN:0.06 µM
In vitro
Werner syndrome RecQ helicase-IN-4 is an inhibitor of RecQ DNA helicase (WRN) with an IC50 value of 0.06 µM.
In vivo
Werner syndrome RecQ helicase-IN-4 (240 mg/kg, 18 days, orally) showed anticancer activity in SW48 xenografted mice. [1]
Chemical Properties
Molecular Weight666.65
FormulaC32H33F3N8O5
Cas No.2869954-53-8
SmilesO=C(C1=NC=CC=C1O)N2CCN(C=3C(=O)N4N=C(N=C4N(C3CC)CC(=O)NC5=CC=C(C=C5C)C(F)(F)F)C6=CCOCC6)CC2
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (120 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5000 mL7.5002 mL15.0004 mL75.0019 mL
5 mM0.3000 mL1.5000 mL3.0001 mL15.0004 mL
10 mM0.1500 mL0.7500 mL1.5000 mL7.5002 mL
20 mM0.0750 mL0.3750 mL0.7500 mL3.7501 mL
50 mM0.0300 mL0.1500 mL0.3000 mL1.5000 mL
100 mM0.0150 mL0.0750 mL0.1500 mL0.7500 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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