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Anti-Cullin 2 Antibody (5U128)

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Catalog No. TMAC-01019

Anti-Cullin 2 Antibody (5U128) is a Rabbit antibody targeting Cullin 2. Anti-Cullin 2 Antibody (5U128) can be used in WB,IHC,IP.

Anti-Cullin 2 Antibody (5U128)

Anti-Cullin 2 Antibody (5U128)

😃Good
Catalog No. TMAC-01019
Anti-Cullin 2 Antibody (5U128) is a Rabbit antibody targeting Cullin 2. Anti-Cullin 2 Antibody (5U128) can be used in WB,IHC,IP.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Cullin 2 Antibody (5U128) is a Rabbit antibody targeting Cullin 2. Anti-Cullin 2 Antibody (5U128) can be used in WB,IHC,IP.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000; IHC: 1:50-200; IP: 1:10-50
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundCullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
49917
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 89 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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