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GFB-12811 (Synonyms: GFB12811)

Name: GFB-12811
Brand: TargetMol
SKU: T62695
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T62695 Copy Product Info

Purity: 98.88%

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GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.

GFB-12811

Copy Product Info

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Catalog No. T62695

Synonyms GFB12811

GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.

Cas No. 2775311-17-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$313	In Stock	In Stock
5 mg	$787	In Stock	In Stock
10 mg	$1,130	In Stock	In Stock
25 mg	$1,820	In Stock	In Stock
50 mg	$2,480	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$777	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.88%

Appearance:Solid

Color:Orange

Resource Download

COA HPLC HNMR FNMR

Product Introduction

Bioactivity

Description	GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.
Targets&IC50	CDK5:2.3 nM, CDK2-CyclinA:211 nM, CDK7-CyclinH-MAT1:718 nM, CDK9-CyclinT1:894 nM
In vitro	GFB-12811 is a highly selective CDK5 inhibitor with IC50=2.3 nM. [1]
Synonyms	GFB12811

Chemical Properties

Molecular Weight	449.44
Formula	C₂₂H₂₃F₄N₅O
Cas No.	2775311-17-4
Smiles	[C@](C)(O)(C1=NC2=C(C=C1)C=NC(NC=3C=C(C(F)(F)F)N=CC3F)=C2)C4CCN(C)CC4

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2250 mL	11.1250 mL	22.2499 mL	111.2496 mL
5 mM	0.4450 mL	2.2250 mL	4.4500 mL	22.2499 mL
10 mM	0.2225 mL	1.1125 mL	2.2250 mL	11.1250 mL
20 mM	0.1112 mL	0.5562 mL	1.1125 mL	5.5625 mL
50 mM	0.0445 mL	0.2225 mL	0.4450 mL	2.2250 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc