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FD-IN-1

Name: FD-IN-1
Brand: TargetMol
SKU: T11269
Rating: 4.5 (1 reviews)

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Catalog No. T11269Cas No. 1646682-14-5

FD-IN-1 (Compound 12) is an orally active Factor D (FD) inhibitor (IC50=12 nM) that also inhibits Factor XIa (FXIa) and Tryptase β2 with IC50 values of 7.7 and 6.5 μM, respectively.

FD-IN-1

😃Good

Catalog No. T11269Cas No. 1646682-14-5

FD-IN-1 (Compound 12) is an orally active Factor D (FD) inhibitor (IC50=12 nM) that also inhibits Factor XIa (FXIa) and Tryptase β2 with IC50 values of 7.7 and 6.5 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	6-8 weeks	6-8 weeks
5 mg	Preferential	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	FD-IN-1 (Compound 12) is an orally active Factor D (FD) inhibitor (IC50=12 nM) that also inhibits Factor XIa (FXIa) and Tryptase β2 with IC50 values of 7.7 and 6.5 μM, respectively.
In vitro	FD-IN-1 (Compound 12) shows activity in the alternative pathway (AP) functional inhibition assay: in an in vitro membrane attack complex (MAC) deposition test using 50% human whole blood (WB), its half-maximal inhibitory concentration (IC₅₀) was found to be 0.26 μM[1].
In vivo	At a dose of 10 mg/kg administered via oral gavage, FD-IN-1 fully inhibited the activity of the alternative pathway (AP) in human factor D knock-in mice, and this inhibitory effect was sustained for up to 10 hours[1].

Chemical Properties

Molecular Weight	377.43
Formula	C₂₃H₂₃NO₄
Cas No.	1646682-14-5
Smiles	C(OC1=C(CC(O)=O)C=CC=C1)C=2C=C(C=CC2)C3=CC([C@@H](CO)N)=CC=C3
Relative Density.	1.251 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (127.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6495 mL	13.2475 mL	26.4950 mL	132.4749 mL
5 mM	0.5299 mL	2.6495 mL	5.2990 mL	26.4950 mL
10 mM	0.2649 mL	1.3247 mL	2.6495 mL	13.2475 mL
20 mM	0.1325 mL	0.6624 mL	1.3247 mL	6.6237 mL
50 mM	0.0530 mL	0.2649 mL	0.5299 mL	2.6495 mL
100 mM	0.0265 mL	0.1325 mL	0.2649 mL	1.3247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc