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Ceapin-A7

Name: Ceapin-A7
Brand: TargetMol
SKU: T9110
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9110Cas No. 2323027-38-7

Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions.

Ceapin-A7

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Purity: 99.74%

Catalog No. T9110Cas No. 2323027-38-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$155	-	In Stock
50 mg	$263	-	In Stock
100 mg	$427	-	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White to Pink

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COA HNMR LCMS

Product Introduction

Ceapin-A7 AI Summary

Ceapin-A7 is a bioactive compound that modulates ATF6 activity in human U2OS cells, particularly in the presence of the ER stress inducer thapsigargin. At concentrations of both 1 uM and 10 uM, it exhibited less than 50.0% activity as measured by the TRE-luciferase reporter assay relative to the control, suggesting an inhibitory effect on ATF6 under ER stress conditions. The compound also demonstrates good oral bioavailability in Balb/C mouse plasma and has moderate metabolic stability in liver microsomes across different species. Furthermore, it shows inhibitory effects on several cytochrome P450 enzymes involved in drug metabolism, such as CYP2B6 and CYP2C8. This bioactivity profile suggests Ceapin-A7 has potential for further investigation in drug development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions.
Targets&IC50	ATF6α:0.59 μM

Chemical Properties

Molecular Weight	470.32
Formula	C₂₀H₁₂F₆N₄O₃
Cas No.	2323027-38-7
Smiles	FC(F)(F)c1ccc(Cn2cc(NC(=O)c3cc(on3)-c3ccco3)cn2)c(c1)C(F)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (212.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1262 mL	10.6311 mL	21.2621 mL	106.3106 mL
5 mM	0.4252 mL	2.1262 mL	4.2524 mL	21.2621 mL
10 mM	0.2126 mL	1.0631 mL	2.1262 mL	10.6311 mL
20 mM	0.1063 mL	0.5316 mL	1.0631 mL	5.3155 mL
50 mM	0.0425 mL	0.2126 mL	0.4252 mL	2.1262 mL
100 mM	0.0213 mL	0.1063 mL	0.2126 mL	1.0631 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc