AMPA receptor modulator-9

Name: AMPA receptor modulator-9
Brand: TargetMol
SKU: T213620
Rating: 4.5 (1 reviews)

Catalog No. T213620 Copy Product Info

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AMPA receptor modulator-9 is a selective, orally active positive allosteric modulator of AMPARs, capable of crossing the blood-brain barrier. It selectively enhances AMPAR activity in human and rat models, with an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. The compound upregulates BDNF protein expression in primary rat cortical neuron cultures and enhances AMPA-mediated excitatory postsynaptic responses in rats and mice. AMPA receptor modulator-9 is applicable for cognitive disorder studies.

AMPA receptor modulator-9

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Catalog No. T213620

AMPA receptor modulator-9

Cas No. 1204572-46-2

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	AMPA receptor modulator-9 is a selective, orally active positive allosteric modulator of AMPARs, capable of crossing the blood-brain barrier. It selectively enhances AMPAR activity in human and rat models, with an EC2x value of 0.96 μM in rat embryonic cortical primary neurons. The compound upregulates BDNF protein expression in primary rat cortical neuron cultures and enhances AMPA-mediated excitatory postsynaptic responses in rats and mice. AMPA receptor modulator-9 is applicable for cognitive disorder studies.
In vitro	AMPA receptor modulator-9 (Compound 14o) enhances AMPA receptor activity in primary neuronal cultures from rat embryonic cortex with an EC 2x value of 0.96 μM. In Xenopus oocytes injected with rat cortical or human hippocampal poly(AM + ) mRNA, it increases AMPA-induced inward currents (rat cortical mRNA: EC 50 = 9.9 μM; human hippocampal mRNA: EC 50 = 18 μM). Additionally, AMPA receptor modulator-9 (3-30 μM) modulates AMPA-mediated excitatory postsynaptic responses in the CA1 region of rat hippocampal slices by enhancing response area. It also upregulates BDNF protein expression in a dose-dependent manner in rat primary cortical neuronal cultures at concentrations of 0.3-10 μM over 24 hours.
In vivo	Compound 14o, an AMPA receptor modulator, administered as a single intraperitoneal injection at doses ranging from 0.01 to 30 mg/kg, significantly enhances the induction and maintenance of long-term potentiation in the dentate gyrus of anesthetized rats.

Chemical Properties

Molecular Weight	293.16
Formula	C₁₀H₁₀Cl₂N₂O₂S
Cas No.	1204572-46-2
Smiles	O=S1(=O)NCN(C2=CC(Cl)=C(Cl)C=C21)C3CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc