Anti-Wnt5a Polyclonal Antibody

Name: Anti-Wnt5a Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01986
Rating: 4.5 (1 reviews)

(Synonyms: WNT5A, Protein Wnt-5a) Copy Product Info

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Synonyms: WNT5A, Protein Wnt-5a

Catalog No. TMAB-01986 Copy Product Info

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Anti-Wnt5a Polyclonal Antibody is a Rabbit antibody targeting Wnt5a. Anti-Wnt5a Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.

Anti-Wnt5a Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-Wnt5a Polyclonal Antibody is a Rabbit antibody targeting Wnt5a. Anti-Wnt5a Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Synonyms	WNT5A, Protein Wnt-5a
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Pig,Cow,Rabbit)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human WNT5A
Antigen Species	Human
Gene Name	WNT5A
Gene ID	7474
Protein Name	Protein Wnt-5a
Uniprot ID	P41221
Biology Area	PTC & Wnt pathway,Neural Signal Transduction,Secreted
Function	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.