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PKR-IN-2

Name: PKR-IN-2
Brand: TargetMol
SKU: T12499
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12499Cas No. 1628428-01-2

PKR-IN-2 is a activator of pyruvate kinase (PKR).

PKR-IN-2

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Purity: 99.14%

Catalog No. T12499Cas No. 1628428-01-2

PKR-IN-2 is a activator of pyruvate kinase (PKR).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$168	In Stock	In Stock
25 mg	$278	In Stock	In Stock
50 mg	$392	In Stock	In Stock
100 mg	$558	-	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.14%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

PKR-IN-2 AI Summary

PKR-IN-2 activates wild type PKR as well as the PKR mutant types R510Q and R532W, with AC50 values below 100.0 nM as measured by various assays. These bioactivities indicate that PKR-IN-2 may have potential as an activator of PKR signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

PKR-IN-2 is a activator of pyruvate kinase (PKR).

Chemical Properties

Molecular Weight	468.57
Formula	C₂₄H₂₈N₄O₄S
Cas No.	1628428-01-2
Smiles	CC(C)CC1(O)CCN(CC1)C(=O)c1ccc(NS(=O)(=O)c2cccc3nccnc23)cc1
Relative Density.	1.336 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (96.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1342 mL	10.6708 mL	21.3415 mL	106.7076 mL
5 mM	0.4268 mL	2.1342 mL	4.2683 mL	21.3415 mL
10 mM	0.2134 mL	1.0671 mL	2.1342 mL	10.6708 mL
20 mM	0.1067 mL	0.5335 mL	1.0671 mL	5.3354 mL
50 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1342 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc