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SR142948A

Name: SR142948A
Brand: TargetMol
SKU: T28845
Rating: 4.5 (1 reviews)

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Catalog No. T28845Cas No. 184162-21-8

Alias SR142948 HCl, SR 142948A, SR 142948 HCl

SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release.

SR142948A

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Catalog No. T28845Alias SR142948 HCl, SR 142948A, SR 142948 HClCas No. 184162-21-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$293	3-6 months	3-6 months
25 mg	$789	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release.
Targets&IC50	Inositol monophosphate (IP₁) formation via NT receptor (HT29 cells):3.9  nM
In vitro	SR142948A HCl showed potent NT receptor antagonism in HT29 cells and CHO cells expressing human NT receptors, inhibiting inositol monophosphate formation and calcium mobilization, respectively (IC₅₀ = 3.9 nM for IP₁ formation)[1].
In vivo	The in vivo activity of SR142948A HCl was evaluated in rats via intraperitoneal injection (0.1–100 mg/kg) to assess the effects on antipsychotic-related behaviors. In the latent inhibition model (0.1–10 mg/kg), SR142948A HCl blocked the normal acquisition of stimulus inhibition, and in the isolation-induced PPI deficit model (100 mg/kg), SR142948A HCl prevented haloperidol- and quetiapine-induced recovery of prepulse inhibition, indicating interference with neurotensin-dependent antipsychotic effects[1].
Synonyms	SR142948 HCl, SR 142948A, SR 142948 HCl

Chemical Properties

Molecular Weight	722.31
Formula	C₃₉H₅₂ClN₅O₆
Cas No.	184162-21-8
Smiles	Cl.O=C(O)C1(NC(=O)C2=NN(C3=CC=C(C=C3C(C)C)C(=O)N(C)CCCN(C)C)C(=C2)C=4C(OC)=CC=CC4OC)C5CC6CC(C5)CC1C6
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8 mg/mL (11.08 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3844 mL	6.9222 mL	13.8445 mL	69.2224 mL
5 mM	0.2769 mL	1.3844 mL	2.7689 mL	13.8445 mL
10 mM	0.1384 mL	0.6922 mL	1.3844 mL	6.9222 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc