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SR142948A
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Catalog No. T28845Cas No. 184162-21-8
Alias SR142948 HCl, SR 142948A, SR 142948 HCl
SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release.
SR142948A
😃Good
Catalog No. T28845Alias SR142948 HCl, SR 142948A, SR 142948 HClCas No. 184162-21-8
SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $293 | 3-6 months | 3-6 months | |
| 25 mg | $789 | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist capable of blocking hypothermia and analgesic effects induced by intracerebroventricular injection of NT, and capable of concentration- and volume-dependent blockade of NMDA-induced dopamine release. |
| Targets&IC50 | Inositol monophosphate (IP₁) formation via NT receptor (HT29 cells):3.9 nM |
| In vitro | SR142948A HCl showed potent NT receptor antagonism in HT29 cells and CHO cells expressing human NT receptors, inhibiting inositol monophosphate formation and calcium mobilization, respectively (IC₅₀ = 3.9 nM for IP₁ formation)[1]. |
| In vivo | The in vivo activity of SR142948A HCl was evaluated in rats via intraperitoneal injection (0.1–100 mg/kg) to assess the effects on antipsychotic-related behaviors. In the latent inhibition model (0.1–10 mg/kg), SR142948A HCl blocked the normal acquisition of stimulus inhibition, and in the isolation-induced PPI deficit model (100 mg/kg), SR142948A HCl prevented haloperidol- and quetiapine-induced recovery of prepulse inhibition, indicating interference with neurotensin-dependent antipsychotic effects[1]. |
| Synonyms | SR142948 HCl, SR 142948A, SR 142948 HCl |
| Molecular Weight | 722.31 |
| Formula | C39H52ClN5O6 |
| Cas No. | 184162-21-8 |
| Smiles | Cl.O=C(O)C1(NC(=O)C2=NN(C3=CC=C(C=C3C(C)C)C(=O)N(C)CCCN(C)C)C(=C2)C=4C(OC)=CC=CC4OC)C5CC6CC(C5)CC1C6 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 8 mg/mL (11.08 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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