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DSR-6434

Name: DSR-6434
Brand: TargetMol
SKU: T11108
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11108Cas No. 1059070-10-8

DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.

DSR-6434

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Purity: 99.78%

Catalog No. T11108Cas No. 1059070-10-8

DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	Preferential	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.78%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.
Targets&IC50	TLR7:7.2 nM (EC50, Human), TLR7:4.6 nM (EC50, Mice)
In vitro	To evaluate the specificity of DSR-6434 for TLR7, a NF-κB-driven reporter assay was conducted in HEK293 cells engineered to express hTLR7, TLR8, or TLR9. This assay determines specificity through NF-κB activation upon successful receptor binding. Results demonstrate that DSR-6434 selectively stimulates reporter gene activity in cells expressing hTLR7, but not in those expressing the structurally similar hTLR8 or hTLR9[1].
In vivo	In B6C3F1 mice, DSR-6434 (0.1-1 mg/kg; i.v.) significantly suppresses lung metastasis[1].

Chemical Properties

Molecular Weight	400.48
Formula	C₁₉H₂₈N₈O₂
Cas No.	1059070-10-8
Smiles	CCCCNc1nc(N)c2[nH]c(=O)n(Cc3ccc(OCCN(C)C)nc3)c2n1
Relative Density.	1.283 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (561.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4970 mL	12.4850 mL	24.9700 mL	124.8502 mL
5 mM	0.4994 mL	2.4970 mL	4.9940 mL	24.9700 mL
10 mM	0.2497 mL	1.2485 mL	2.4970 mL	12.4850 mL
20 mM	0.1249 mL	0.6243 mL	1.2485 mL	6.2425 mL
50 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4970 mL
100 mM	0.0250 mL	0.1249 mL	0.2497 mL	1.2485 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc