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PF-06726304 acetate
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Catalog No. T12428Cas No. 2080306-28-9
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
PF-06726304 acetate
😃Good
Catalog No. T12428Cas No. 2080306-28-9
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $783 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity. |
| Targets&IC50 | EZH2 (Y641N):3.0 nM (ki), EZH2 (WT):0.7 nM (ki) |
| In vitro | PF-06726304 inhibits the proliferation of Karpas-422 cells that harbor wild-type EZH2 (IC50 of 25 nM)[1]. |
| In vivo | In a subcutaneous Karpas-422 xenograft model,PF-06726304 inhibits tumor growth and induces robust modulation of downstream biomarkers [1]. |
| Molecular Weight | 506.38 |
| Formula | C24H25Cl2N3O5 |
| Cas No. | 2080306-28-9 |
| Smiles | O=C1NC(=CC(=C1CN2C(=O)C3=C(Cl)C(=CC(Cl)=C3CC2)C=4C(=NOC4C)C)C)C.O=C(O)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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