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HDAC-IN-42

Catalog No. T61630 CAS 2454024-18-9

HDAC-IN-42 (compound 14f) is a highly potent and selective inhibitor of histone deacetylase (HDAC) enzymes, with IC50 values of 0.19 μM for HDAC1 and 4.98 μM for HDAC6. It exhibits remarkable anticancer properties and inhibits cell proliferation. Additionally, HDAC-IN-42 induces apoptosis and causes cell cycle arrest specifically at the G2/M phase [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HDAC-IN-42, CAS 2454024-18-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 2,140.00
50 mg	6-8 weeks	$ 2,785.00
100 mg	6-8 weeks	$ 3,520.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

HDAC-IN-42 (compound 14f) exhibits anti-proliferative effects on various cancer cell lines, achieving half-maximal inhibitory concentrations (C50s) of 9.56 μM for MCF-7, 13.32 μM for HCT-116, 10.46 μM for HepG2, and 6.91 μM for HeLa cells. At concentrations of 1, 5, and 10 μM over 24 hours, it diminishes colony formation in HeLa cells and enhances the expression levels of histone H3 and α-tubulin, indicating an impact on cell structure and genetic material packaging. Furthermore, when applied for 48 hours, HDAC-IN-42 prompts apoptosis and halts the cell cycle at the G2/M phase, demonstrating its potential as a targeted therapeutic agent [1].

Molecular Weight	381.34
Formula	C20H15NO7
CAS No.	2454024-18-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HDAC-IN-42 2454024-18-9 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.