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AI-10-104
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Catalog No. T85607Cas No. 1881276-00-1
AI-10-104 acts as an inhibitor of the runt-related transcription factor (RUNX), increasing cytotoxic effects in myeloma cells [1].
AI-10-104
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Catalog No. T85607Cas No. 1881276-00-1
AI-10-104 acts as an inhibitor of the runt-related transcription factor (RUNX), increasing cytotoxic effects in myeloma cells [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,650 | 4-6 weeks | 4-6 weeks | |
| 50 mg | $2,240 | 4-6 weeks | 4-6 weeks | |
| 100 mg | $2,760 | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | AI-10-104 acts as an inhibitor of the runt-related transcription factor (RUNX), increasing cytotoxic effects in myeloma cells [1]. |
| In vitro | AI-10-104 (0-10 μM) inhibits RUNX by dissociating the RUNXs-IKZFs complex, thereby enhancing the antiproliferative and cytotoxic effects of lenalidomide (CC-5013) on myeloma cells [1]. Western Blot analysis [1], using a concentration of 0-10 μM in HEK293T cells, shows a reduction in IKZF3 and CBFβ levels. Cell proliferation assays [1] conducted on OPM-1, KMS-11, and U266 cell lines at a concentration of 1 μM revealed maintained cell viability with moderate inhibition of OPM-1 cell proliferation. |
| Molecular Weight | 309.24 |
| Formula | C14H10F3N3O2 |
| Cas No. | 1881276-00-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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