Foxy-5 acetate

Name: Foxy-5 acetate
Brand: TargetMol
SKU: TP1565L
Rating: 4.5 (1 reviews)

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Catalog No. TP1565L

Alias Foxy-5 acetate(881188-51-8 free base)

Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer cells triggers cytosolic free calcium signaling without affecting β-catenin activation.

Foxy-5 acetate

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Catalog No. TP1565LAlias Foxy-5 acetate(881188-51-8 free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$121	Inquiry	Inquiry
5 mg	$273	Inquiry	Inquiry
10 mg	$397	Inquiry	Inquiry
25 mg	$736	Inquiry	Inquiry
50 mg	$1,117	Inquiry	Inquiry
100 mg	$1,654	Inquiry	Inquiry
200 mg	$2,477	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer cells triggers cytosolic free calcium signaling without affecting β-catenin activation.
In vivo	In an orthotopic mouse model, Foxy-5 acetate effectively reduces the metastatic spread of Wnt 5A-low prostate cancer cells[2]. In a xenograft mouse model of human colonic cancer, Foxy-5 acetate reduces the number of colonic cancer stem cells[3].
Synonyms	Foxy-5 acetate(881188-51-8 free base)

Chemical Properties

Molecular Weight	754.83
Formula	C₂₈H₄₆N₆O₁₄S₂
Smiles	CC(C)C[C@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC=O)CCSC)=O)CC(O)=O)=O)=O)CS)=O)CCC(O)=O)=O)C(O)=O.CC(O)=O
Relative Density.	1.31g/cm3
Sequence	Met-Asp-Gly-Cys-Glu-Leu
Sequence Short	MDGCEL

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc