SIRT5 inhibitor 4

Name: SIRT5 inhibitor 4
Brand: TargetMol
SKU: T61457
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61457Cas No. 708992-34-1

SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitor with an IC50 value of 26.4 μM for SIRT5 and no inhibitory effect on SIRT1/2/3 isoforms at 400 μM, with anticancer potential.

SIRT5 inhibitor 4

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Purity: 99.97%

Catalog No. T61457Cas No. 708992-34-1

Pack Size	Price	Availability
1 mg	$293	In Stock
5 mg	$722	In Stock
10 mg	$987	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock

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Purity:99.97%

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Product Introduction

Bioactivity

Description	SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitor with an IC50 value of 26.4 μM for SIRT5 and no inhibitory effect on SIRT1/2/3 isoforms at 400 μM, with anticancer potential.
Targets&IC50	SIRT5:26.4 μM
In vitro	SIRT5 inhibitor 4 was identified as a selective SIRT5 inhibitor (IC₅₀ = 26.4 ± 0.8 μM) with no inhibition on SIRT1–3[1].

Chemical Properties

Molecular Weight	369.39
Formula	C₁₈H₁₅N₃O₄S
Cas No.	708992-34-1
Smiles	O=C(O)C1=CC=C(C=C1O)NC2=NC(=CS2)C=3C=CC(=CC3)NC(=O)C
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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