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1,3-Dimethyluric acid

Name: 1,3-Dimethyluric acid
Brand: TargetMol
SKU: T8075
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T8075 Copy Product Info

Purity: 99.94%

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1,3-Dimethyluric acid, a product of theophylline metabolism in man, is one of the purine components in urinary calculi.

1,3-Dimethyluric acid

Copy Product Info

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Catalog No. T8075

1,3-Dimethyluric acid, a product of theophylline metabolism in man, is one of the purine components in urinary calculi.

Cas No. 944-73-0

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

1,3-Dimethyluric acid AI Summary

1,3-Dimethyluric acid demonstrates a range of biological activities. It has a binding affinity with the DNA intercalator Acridine orange, characterized by a binding constant (Kass) of 38.5 M-1. The compound exhibits significant antioxidant properties, effectively scavenging 10 µM 1,1-diphenylpicrylhydrazyl (DPPH) with an RC10 value of 3.5 µM, and showing a 36.0% inhibition rate of oxidative processes in bovine heart mitochondria at 100 µM. Additionally, 1,3-Dimethyluric acid has been observed to induce insulin release in rat pancreatic beta-cells, achieving an insulin release rate of 8.48 ng/islet/h at a concentration of 1 mM after 15 minutes. In terms of enzymatic inhibition, 1,3-Dimethyluric acid inhibits the Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase with IC50 values between 64,000 nM and 99,000 nM depending on the assay conditions. It is also tested for its inhibitory activity against Glutaminase (GLS) with a potency of 10,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

1,3-Dimethyluric acid, a product of theophylline metabolism in man, is one of the purine components in urinary calculi.

Chemical Properties

Molecular Weight	196.16
Formula	C₇H₈N₄O₃
Cas No.	944-73-0
Smiles	Cn1c2[nH]c(=O)[nH]c2c(=O)n(C)c1=O
Relative Density.	1.4375 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 1.97 mg/mL (10.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0979 mL	25.4894 mL	50.9788 mL	254.8940 mL
5 mM	1.0196 mL	5.0979 mL	10.1958 mL	50.9788 mL
10 mM	0.5098 mL	2.5489 mL	5.0979 mL	25.4894 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc