Shopping Cart
Remove All
Your shopping cart is currently empty
FB231
Catalog No. T213472 Copy Product Info
🥰Excellent
FB231 is a Parkin activator that can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response (ISR). It reduces the threshold for PINK1/Parkin-mediated mitophagy induced by mitochondrial toxins and disrupts iron-dependent pathways. FB231 is applicable in research on neurological disorders, including Parkinson's disease.
FB231
Copy Product Info🥰Excellent
Catalog No. T213472
FB231 is a Parkin activator that can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response (ISR). It reduces the threshold for PINK1/Parkin-mediated mitophagy induced by mitochondrial toxins and disrupts iron-dependent pathways. FB231 is applicable in research on neurological disorders, including Parkinson's disease.
FB231
Cas No. 2166045-37-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FB231 is a Parkin activator that can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response (ISR). It reduces the threshold for PINK1/Parkin-mediated mitophagy induced by mitochondrial toxins and disrupts iron-dependent pathways. FB231 is applicable in research on neurological disorders, including Parkinson's disease. |
| In vitro | FB231 activates Parkin and enhances Parkin-mediated mitophagy induced by low-dose Oligomycin/Antimycin (O/A) with an EC50 value of 0.67 μM. In YFP-Parkin/mt-Keima expressing HeLa cells and SH-SY5Y cells with endogenous Parkin expression, FB231 (0.3125-20 μM, 6-24 h) reduces the threshold of O/A-induced mitophagy. It effectively chelates Fe2+ with an EC50 of 23.2 μM. Additionally, FB231 (6 h) increases mitochondrial oxygen consumption rate (OCR) in wild-type HeLa cells and decreases sensitivity to the Complex V inhibitor, Oligomycin. FB231 (3.125-20 μM, 24 h) reduces the survival rate of HeLa and SH-SY5Y cells. It also induces expression of ISR markers ATF3, ATF4, and IFRD1 in wild-type HeLa cells, YFP-Parkin HeLa cells, and PINK1 knockout HeLa cells (10 μM, 16 h). Furthermore, FB231 (40 μM) stabilizes the HECT domain E3 ligase HERC4 while destabilizing the iron response protein IREB2. |
| Molecular Weight | 411.47 |
| Formula | C24H21N5O2 |
| Cas No. | 2166045-37-8 |
| Smiles | O=C(NC=1N=C(NC(=O)C=2C=CC=CC2C)N(N1)C=3C=CC=CC3)C=4C=CC=CC4C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy FB231 | purchase FB231 | FB231 cost | order FB231 | FB231 in vitro | FB231 formula | FB231 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.