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Anti-MTUS1 Polyclonal Antibody
Catalog No. TMAB-09086 Copy Product Info
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Anti-MTUS1 Polyclonal Antibody is a Rabbit antibody targeting MTUS1. Anti-MTUS1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-MTUS1 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-09086
Anti-MTUS1 Polyclonal Antibody is a Rabbit antibody targeting MTUS1. Anti-MTUS1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-MTUS1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-MTUS1 Polyclonal Antibody is a Rabbit antibody targeting MTUS1. Anti-MTUS1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Dog,Cow,Horse,Rabbit) |
| Verified Activity | 1. Sample: Uterus (mouse) Lysate at 40 μg Primary: Anti-MTUS1/Angiotensin II Type 2 Receptor (TMAB-09086) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 141 kD Observed band size: 135 kD 2. Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (MTUS1 Angiotensin II Type 2 Receptor) Polyclonal Antibody, Unconjugated (TMAB-09086) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion. Golgi apparatus (By similarity). Cell membrane (By similarity). Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin-II (By similarity). Isoform 1: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. |
| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human MTUS1 |
| Antigen Species | Human |
| Gene Name | MTUS1 |
| Gene ID | |
| Protein Name | Microtubule-associated tumor suppressor 1 |
| Uniprot ID | |
| Function | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. |
| Molecular Weight | Theoretical: 141 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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