Anti-CD4 Antibody (7V608) (Synonyms: Ly-4, L3T4, CD4 molecule)

Name: Anti-CD4 Antibody (7V608)
Brand: TargetMol
SKU: TMAY-00771
Rating: 4.5 (1 reviews)

Catalog No. TMAY-00771 Copy Product Info

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Anti-CD4 Antibody (7V608) is a Rabbit antibody targeting CD4. Anti-CD4 Antibody (7V608) can be used in ELISA,IHC-P.

Anti-CD4 Antibody (7V608)

Copy Product Info

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Catalog No. TMAY-00771

Synonyms Ly-4, L3T4, CD4 molecule

Anti-CD4 Antibody (7V608) is a Rabbit antibody targeting CD4. Anti-CD4 Antibody (7V608) can be used in ELISA,IHC-P.

Anti-CD4 Antibody
(7V608)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$198	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-CD4 Antibody (7V608) is a Rabbit antibody targeting CD4. Anti-CD4 Antibody (7V608) can be used in ELISA,IHC-P.
Synonyms	Ly-4, L3T4, CD4 molecule
Ig Type	Rabbit IgG
Clone	7V608
Reactivity	Human
Specificity	Human CD4
Verified Activity	1. Immunochemical staining of human CD4 in human spleen with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human CD4 in human tonsil with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human CD4 in human lymph node with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
Application	ELISA IHC-P
Recommended Dose	ELISA: 1:5000-1:10000; IHC-P: 1:200-1:1000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human CD4 (rh CD4; TMPY-01400; NP_000607.1; Met1-Trp390).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen-presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human CD4 Protein (TMPY-01400)
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.