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Anti-CD4 Antibody (7V608)
😃Good
Catalog No. TMAY-00771
Alias Ly-4, L3T4, CD4 molecule
Anti-CD4 Antibody (7V608) is a Rabbit antibody targeting CD4. Anti-CD4 Antibody (7V608) can be used in ELISA,IHC-P.
Anti-CD4 Antibody (7V608)
Anti-CD4 Antibody (7V608)
😃Good
Catalog No. TMAY-00771Alias Ly-4, L3T4, CD4 molecule
Anti-CD4 Antibody (7V608) is a Rabbit antibody targeting CD4. Anti-CD4 Antibody (7V608) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-CD4 Antibody (7V608) is a Rabbit antibody targeting CD4. Anti-CD4 Antibody (7V608) can be used in ELISA,IHC-P. |
| Alias | Ly-4, L3T4, CD4 molecule |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7V608 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CD4 in human spleen with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human CD4 in human tonsil with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human CD4 in human lymph node with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:200-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD4 (rh CD4; TMPY-01400; NP_000607.1; Met1-Trp390). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen-presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD4 Protein (TMPY-01400) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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