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UCT943

Name: UCT943
Brand: TargetMol
SKU: T13246
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13246Cas No. 1450666-80-4

UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).

UCT943

🥰Excellent

Purity: 99.87%

Catalog No. T13246Cas No. 1450666-80-4

UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	In Stock	In Stock
2 mg	$160	In Stock	In Stock
5 mg	$273	In Stock	In Stock
10 mg	$395	In Stock	In Stock
25 mg	$636	In Stock	In Stock
50 mg	$858	In Stock	In Stock
100 mg	$1,150	In Stock	In Stock
500 mg	$2,310	-	In Stock
1 mL x 10 mM (in DMSO)	$294	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).
Targets&IC50	PvPI4K:23 nM
In vitro	UCT943 maintains a high degree of selectivity (>200-fold) for parasite PI4K versus human PI4Kβ isoenzyme (IC50 = 5.4 μM) in vitro, and its inhibition is associated with immunosuppressive effects[1].
In vivo	In vivo, UCT943 shows good efficacy in the Plasmodium vivax (3-10 mg/kg; orally) and P. falciparum NSG mouse models (0.01-10 mg/kg; orally). UCT943 (10 mg/kg; p.o.) reduces parasitemia by >99.9% in the mouse P. berghei infection model and cures all mice (MSD>30)[1].

Chemical Properties

Molecular Weight	427.42
Formula	C₂₂H₂₀F₃N₅O
Cas No.	1450666-80-4
Smiles	Nc1ncc(nc1-c1ccc(cc1)C(F)(F)F)-c1ccc(cc1)C(=O)N1CCNCC1
Relative Density.	1.321 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (467.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3396 mL	11.6981 mL	23.3962 mL	116.9810 mL
5 mM	0.4679 mL	2.3396 mL	4.6792 mL	23.3962 mL
10 mM	0.2340 mL	1.1698 mL	2.3396 mL	11.6981 mL
20 mM	0.1170 mL	0.5849 mL	1.1698 mL	5.8490 mL
50 mM	0.0468 mL	0.2340 mL	0.4679 mL	2.3396 mL
100 mM	0.0234 mL	0.1170 mL	0.2340 mL	1.1698 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc