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YHO-13177

Name: YHO-13177
Brand: TargetMol
SKU: T4595
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4595Cas No. 912287-56-0

Alias YHO13177, YHO 13177

YHO-13177 is a potent and specific inhibitor of BCRP, which enhances the cytotoxicity of SN-38 in cancer cells without affecting P-glycoprotein–mediated paclitaxel resistance in [MDR1]-transduced human leukemia [K562] cells.

YHO-13177

🥰Excellent

Purity: 98.78%

Catalog No. T4595Alias YHO13177, YHO 13177Cas No. 912287-56-0

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$76	In Stock
10 mg	$113	In Stock
25 mg	$228	In Stock
50 mg	$339	In Stock
100 mg	$543	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

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Batch Information

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Purity:98.78%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	YHO-13177 is a potent and specific inhibitor of BCRP, which enhances the cytotoxicity of SN-38 in cancer cells without affecting P-glycoprotein–mediated paclitaxel resistance in [MDR1]-transduced human leukemia [K562] cells.
Synonyms	YHO13177, YHO 13177

Chemical Properties

Molecular Weight	370.47
Formula	C₂₀H₂₂N₂O₃S
Cas No.	912287-56-0
Smiles	COc1ccc(cc1OC)C(=C\c1ccc(s1)N1CCC(O)CC1)\C#N
Relative Density.	1.266 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (121.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6993 mL	13.4964 mL	26.9927 mL	134.9637 mL
5 mM	0.5399 mL	2.6993 mL	5.3985 mL	26.9927 mL
10 mM	0.2699 mL	1.3496 mL	2.6993 mL	13.4964 mL
20 mM	0.1350 mL	0.6748 mL	1.3496 mL	6.7482 mL
50 mM	0.0540 mL	0.2699 mL	0.5399 mL	2.6993 mL
100 mM	0.0270 mL	0.1350 mL	0.2699 mL	1.3496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc