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Anti-PPM1A Antibody (8T936)
😃Good
Catalog No. TMAY-03206
Alias protein phosphatase, Mg2+/Mn2+ dependent, 1A, PP2C-α, PP2Cα, PP2C-ALPHA, PP2Calpha, PP2CA
Anti-PPM1A Antibody (8T936) is a Rabbit antibody targeting PPM1A. Anti-PPM1A Antibody (8T936) can be used in WB.
Anti-PPM1A Antibody (8T936)
Anti-PPM1A Antibody (8T936)
😃Good
Catalog No. TMAY-03206Alias protein phosphatase, Mg2+/Mn2+ dependent, 1A, PP2C-α, PP2Cα, PP2C-ALPHA, PP2Calpha, PP2CA
Anti-PPM1A Antibody (8T936) is a Rabbit antibody targeting PPM1A. Anti-PPM1A Antibody (8T936) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PPM1A Antibody (8T936) is a Rabbit antibody targeting PPM1A. Anti-PPM1A Antibody (8T936) can be used in WB. |
| Alias | protein phosphatase, Mg2+/Mn2+ dependent, 1A, PP2C-α, PP2Cα, PP2C-ALPHA, PP2Calpha, PP2CA |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8T936 |
| Reactivity | Mouse |
| Verified Activity | Anti-PPM1A rabbit monoclonal antibody at 1:500 -Lane A: Jurkat Whole Cell Lysate. -Lane B: MCF7 Whole Cell Lysate. -Lane C: SKBR3 Whole Cell Lysate. -Lane D: Mouse brain Tissue lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:42 kDa. -Observed band size:45 kDa(We are unsure as to the identity of these extra bands.) |
| Application | WB |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PPM1A / PP2CA (rM PPM1A / PP2CA; TMPY-01663; NP_032936.1; Met1-Trp382). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse PPM1A / PP2CA Protein (TMPY-01663) |
| Antigen Species | Mouse |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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