Anti-PPM1A Antibody (8T936)

Name: Anti-PPM1A Antibody (8T936)
Brand: TargetMol
SKU: TMAY-03206
Rating: 4.5 (1 reviews)

(Synonyms: protein phosphatase, Mg2+/Mn2+ dependent, 1A, PP2C-α, PP2Cα, PP2C-ALPHA, PP2Calpha, PP2CA) Copy Product Info

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Synonyms: protein phosphatase, Mg2+/Mn2+ dependent, 1A, PP2C-α, PP2Cα, PP2C-ALPHA, PP2Calpha, PP2CA

Catalog No. TMAY-03206 Copy Product Info

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Anti-PPM1A Antibody (8T936) is a Rabbit antibody targeting PPM1A. Anti-PPM1A Antibody (8T936) can be used in WB.

Anti-PPM1A Antibody
(8T936)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$270	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Description	Anti-PPM1A Antibody (8T936) is a Rabbit antibody targeting PPM1A. Anti-PPM1A Antibody (8T936) can be used in WB.
Synonyms	protein phosphatase, Mg2+/Mn2+ dependent, 1A, PP2C-α, PP2Cα, PP2C-ALPHA, PP2Calpha, PP2CA
Ig Type	Rabbit IgG
Clone	8T936
Reactivity	Mouse
Specificity	Mouse PPM1A

Application	WB
Recommended Dose	WB: 1:500-1:2000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PPM1A / PP2CA (rM PPM1A / PP2CA; TMPY-01663; NP_032936.1; Met1-Trp382).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Mouse PPM1A / PP2CA Protein (TMPY-01663)
Antigen Species	Mouse
Biology Area	Phosphatases and Regulators

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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