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Aloe emodin

Name: Aloe emodin
Brand: TargetMol
SKU: T2843
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2843Cas No. 481-72-1

Alias Rhabarberone, NSC 38628, Aloe-emodin, 3-Hydroxymethylchrysazine

Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.

Aloe emodin

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Purity: 99.61%

Catalog No. T2843Alias Rhabarberone, NSC 38628, Aloe-emodin, 3-HydroxymethylchrysazineCas No. 481-72-1

Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
20 mg	$34	In Stock	In Stock

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Batch Information

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Purity:99.61%

Appearance:Solid

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COA LCMS HNMR

Product Introduction

Aloe emodin AI Summary

Aloe emodin demonstrates diverse bioactivities with moderate lipophilicity, indicated by a LogP of 2.62 in octanol and water. It shows inhibitory activity against several proteases, including Porcine Pancreatic Elastase (18.0%), Human Leukocyte Elastase (21.0%), and Chymotrypsinogen (13.0%) at 63 µM. Additionally, it inhibits nitric oxide production in LPS-activated mouse macrophages with 38.0% inhibition at 10 µM and exhibits cytotoxic effects at 30 µM. In cancer studies, Aloe emodin enhances the proliferation of MCF-7 cells and exhibits significant antiproliferative activity against A431 and PC3 cell lines, with inhibition rates of 73.6% and 63.4% at 20 µM respectively, and shows cytotoxicity across various human cancer cell lines such as SKOV3 and MCF7. Moreover, it possesses antifungal activity and inhibits biofilm formation of Streptococcus mutans LMG 14558 by 99.2% at 50 µg/ml. It demonstrates antiplatelet activity by inhibiting platelet aggregation in rat plasma. As a potential neuroprotective and antioxidant agent, it inhibits acetylcholinesterase activity and mitigates cell death and oxidative stress in rat PC12 cells. In enzyme inhibition, Aloe emodin is effective against human alcohol and aldehyde dehydrogenases, MAO-A (IC50 1770 nm), antiplasmodial activity against Plasmodium falciparum, and alpha-glucosidase enzymes. It also inhibits HDAC6 and shows anti-HCV, anti-HBV, and weak anti-SARS-CoV-2 activities. This compound, with its broad spectrum of bioactivities, including antibacterial properties against multiple strains, suggests potential applications in pharmacology, particularly as an anticancer, anti-inflammatory, antioxidant, and antimicrobial agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.
Targets&IC50	EV71:0.33 μg/mL, JEV:1 μg/mL
Synonyms	Rhabarberone, NSC 38628, Aloe-emodin, 3-Hydroxymethylchrysazine

Chemical Properties

Molecular Weight	270.24
Formula	C₁₅H₁₀O₅
Cas No.	481-72-1
Smiles	O=C1C=2C(C(=O)C=3C1=CC=CC3O)=C(O)C=C(CO)C2
Relative Density.	1.3280 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 18 mg/mL (66.61 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL	185.0207 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL	37.0041 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL	18.5021 mL
20 mM	0.1850 mL	0.9251 mL	1.8502 mL	9.2510 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc