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UK 78282 hydrochloride

Name: UK 78282 hydrochloride
Brand: TargetMol
SKU: T23497
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23497Cas No. 136647-02-4

UK 78282 hydrochloride, a novel potent and selective Kv1.3 blocker.UK 78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.

UK 78282 hydrochloride

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Purity: 99.89%

Catalog No. T23497Cas No. 136647-02-4

UK 78282 hydrochloride, a novel potent and selective Kv1.3 blocker.UK 78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	-	In Stock
5 mg	$139	-	In Stock
10 mg	$243	-	In Stock
25 mg	$405	-	In Stock
50 mg	$578	-	In Stock
100 mg	$763	-	In Stock
200 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

UK 78282 hydrochloride AI Summary

UK 78282 hydrochloride exhibits cell type-dependent bioactivity, showing both inhibitory and stimulatory effects on various cell lines. In HEK293T cells, it manifests both positive and negative growth rates, indicating varying effects on cell viability. For U2OS cells, the compound generally stimulates growth, leading to a positive growth rate. Conversely, in human fibroblasts, UK 78282 hydrochloride predominantly inhibits cell growth, with occasional slight stimulatory effects. Thus, its impact on cell viability varies significantly depending on the cell type..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	UK 78282 hydrochloride, a novel potent and selective Kv1.3 blocker.UK 78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.
Targets&IC50	Kv1.3 channel:200 nM

Chemical Properties

Molecular Weight	466.05
Formula	C₂₉H₃₆ClNO₂
Cas No.	136647-02-4
Smiles	Cl.COc1ccc(CCCN2CCC(COC(c3ccccc3)c3ccccc3)CC2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.28 mM), Sonication is recommended.

Ethanol: < 13.98 mg/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1457 mL	10.7285 mL	21.4569 mL	107.2846 mL
5 mM	0.4291 mL	2.1457 mL	4.2914 mL	21.4569 mL
10 mM	0.2146 mL	1.0728 mL	2.1457 mL	10.7285 mL
20 mM	0.1073 mL	0.5364 mL	1.0728 mL	5.3642 mL
50 mM	0.0429 mL	0.2146 mL	0.4291 mL	2.1457 mL
100 mM	0.0215 mL	0.1073 mL	0.2146 mL	1.0728 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc