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Lactacystin
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Catalog No. T15702Cas No. 133343-34-7
Lactacystin is a natural non-peptide proteasome inhibitor and highly specific anticancer drug that controls the UPS of cellular protein turnover and inhibits alkaline cell proliferation, and is able to be used as a model for studying dementia, induces neurite outgrowth and transiently elevated levels of cAMP, inhibits angiogenesis, triggers apoptosis in glioma cells, and can penetrate the blood-brain barrier (BBB).
Lactacystin
😃Good
Catalog No. T15702Cas No. 133343-34-7
Lactacystin is a natural non-peptide proteasome inhibitor and highly specific anticancer drug that controls the UPS of cellular protein turnover and inhibits alkaline cell proliferation, and is able to be used as a model for studying dementia, induces neurite outgrowth and transiently elevated levels of cAMP, inhibits angiogenesis, triggers apoptosis in glioma cells, and can penetrate the blood-brain barrier (BBB).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μg | TBD | 35 days | |
| 100 μg | $273 | 35 days | |
| 500 μg | TBD | 35 days | |
| 1 mg | TBD | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lactacystin is a natural non-peptide proteasome inhibitor and highly specific anticancer drug that controls the UPS of cellular protein turnover and inhibits alkaline cell proliferation, and is able to be used as a model for studying dementia, induces neurite outgrowth and transiently elevated levels of cAMP, inhibits angiogenesis, triggers apoptosis in glioma cells, and can penetrate the blood-brain barrier (BBB). |
| Targets&IC50 | Proteasome:4.8 μM |
| In vitro | Methods: RA-differentiated SH-SY5Y cells were treated with lactacystin (2.5–10 μg/ml, 48 hours) to select the effective concentration for celastrol studies. Results: Lactacystin at a concentration of 10 μg/ml (26.4 μM) reduced SH-SY5Y cell viability by 40-50%. [3] |
| In vivo | Methods: Lactacystin (5 μg/2 μl) was administered unilaterally into the left SNc of rats to study its effect on rat body weight. Results: Lactacystin can reduce the body weight of rats. [3] |
| Molecular Weight | 376.43 |
| Formula | C15H24N2O7S |
| Cas No. | 133343-34-7 |
| Smiles | C(SC[C@H](NC(C)=O)C(O)=O)(=O)[C@@]1([C@H](C(C)C)O)[C@@H](O)[C@@H](C)C(=O)N1 |
| Relative Density. | 1.367 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 18 mg/mL (47.82 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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