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CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
(Synonyms: TRAP, TNFSF5IMD3, TNFSF5, T-BAM, IGM, HIGM1, CD40LIGM, CD40LG, CD40L, CD40 Ligand, CD154) Copy Product InfoSynonyms: TRAP, TNFSF5IMD3, TNFSF5, T-BAM, IGM, HIGM1, CD40LIGM, CD40LG, CD40L, CD40 Ligand, CD154
Catalog No. TMPK-01398 Copy Product Info
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $51 | Inquiry | Inquiry | |
| 10 μg | $80 | Inquiry | Inquiry | |
| 20 μg | $129 | Inquiry | Inquiry | |
| 50 μg | $248 | Inquiry | Inquiry | |
| 100 μg | $418 | Inquiry | Inquiry | |
| 200 μg | $758 | Inquiry | Inquiry | |
| 500 μg | $1,670 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Immobilized Human CD40, His Tag at 1 μg/ml (100 μl/Well) on the plate. Dose response curve for Human CD40 Ligand (Trimer) , hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA (QC Test). 2. Serial dilutions of Anti-CD40 Antibody were added into Biotinylated Human CD40, His Tag : Human CD40 Ligand (Trimer) , hFc Tag binding reactioins. The half maximal inhibitiory concentration (IC50) is 2.0 μg/ml. |
| Description | CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | P29965 |
| Construction | Met113-Leu261 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | TRAP, TNFSF5IMD3, TNFSF5, T-BAM, IGM, HIGM1, CD40LIGM, CD40LG, CD40L, CD40 Ligand, CD154 |
| Research Background |
| Molecular Weight | 74.9 kDa (predicted). Due to glycosylation, the protein migrates to 75-80 kDa based on Tris-Bis PAGE result. |
| Relative Density. | no data available |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CD40 Ligand Trimer Protein, Human, Recombinant (hFc) chemical structure | CD40 Ligand Trimer Protein, Human, Recombinant (hFc) molecular weight
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