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JNJ-1289

Name: JNJ-1289
Brand: TargetMol
SKU: T60738
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60738Cas No. 792898-18-1

JNJ-1289 is a selective, potent, and competitive inhibitor of human spermine oxidase (hSMOX) with an IC50 value of 50 nM.JNJ-1289 has potential anticancer and anti-inflammatory activity for the study of polyamine catabolic disorders.

JNJ-1289

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Purity: 97.05%

Catalog No. T60738Cas No. 792898-18-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	-	In Stock
5 mg	$217	-	In Stock
10 mg	$306	-	In Stock
25 mg	$517	-	In Stock
50 mg	$685	-	In Stock
100 mg	$917	-	In Stock
200 mg	$1,230	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.05%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	JNJ-1289 is a selective, potent, and competitive inhibitor of human spermine oxidase (hSMOX) with an IC50 value of 50 nM.JNJ-1289 has potential anticancer and anti-inflammatory activity for the study of polyamine catabolic disorders.
In vitro	In a time-dependent manner, JNJ-1289 inhibits hSMOX activity, with assessments at 0 and 2 hours[1]. Initially, JNJ-1289 forms a weak complex with hSMOX, characterized by an apparent Ki value of 1.4 μM. Subsequently, a relatively slow protein isomerization occurs, leading to the formation of the final tightly bound inhibitor-enzyme complex[1].

Chemical Properties

Molecular Weight	308.36
Formula	C₁₆H₁₂N₄OS
Cas No.	792898-18-1
Smiles	N(C1=NC(C=2N3C(=NC2)C=CC=C3)=CS1)C4=CC=C(O)C=C4
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (162.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (8.11 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2430 mL	16.2148 mL	32.4296 mL	162.1481 mL
5 mM	0.6486 mL	3.2430 mL	6.4859 mL	32.4296 mL
10 mM	0.3243 mL	1.6215 mL	3.2430 mL	16.2148 mL
20 mM	0.1621 mL	0.8107 mL	1.6215 mL	8.1074 mL
50 mM	0.0649 mL	0.3243 mL	0.6486 mL	3.2430 mL
100 mM	0.0324 mL	0.1621 mL	0.3243 mL	1.6215 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc