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Anti-BCL2 Antibody (5A692)
😃Good
Catalog No. TMAY-00066
Alias PPP1R50, Bcl-2, B-cell CLL/lymphoma 2
Anti-BCL2 Antibody (5A692) is a Rabbit antibody targeting BCL2. Anti-BCL2 Antibody (5A692) can be used in IHC-P,FCM.
Anti-BCL2 Antibody (5A692)
Anti-BCL2 Antibody (5A692)
😃Good
Catalog No. TMAY-00066Alias PPP1R50, Bcl-2, B-cell CLL/lymphoma 2
Anti-BCL2 Antibody (5A692) is a Rabbit antibody targeting BCL2. Anti-BCL2 Antibody (5A692) can be used in IHC-P,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: IHC-P, FCM Reactivity: Human |
| Alias | PPP1R50, Bcl-2, B-cell CLL/lymphoma 2 |
| Ig Type | Rabbit IgG |
| Clone | 5A692 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human BCL-2 in human tonsil with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human BCL-2 in human sarcoma with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). 3. Flow cytometric analysis of Human BCL2 expression on Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human BCL2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | IHC-P,FCM |
| Recommended Dose | IHC-P: 1:250-1:1000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the N-terminus of the Human Bcl-2. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes. It is expressed in a variety of tissues. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | APC/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | A synthetic peptide: N-terminus of the Human Bcl-2. |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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