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IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated

Catalog No. TMPJ-00291
Synonyms: IL-6R-α, IL-6R-alpha, Interleukin-6 receptor subunit alpha, Interleukin-6 receptor subunit α, IL-6R subunit α, Membrane glycoprotein 80, gp80, CD126, IL-6R subunit alpha, IL-6R 1

Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
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Biological Description
Technical Params
Product Properties
Description Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
Species Human
Expression System Human Cells
Tag C-Avi-6His
Accession Number P08887
Synonyms IL-6R-α, IL-6R-alpha, Interleukin-6 receptor subunit alpha, Interleukin-6 receptor subunit α, IL-6R subunit α, Membrane glycoprotein 80, gp80, CD126, IL-6R subunit alpha, IL-6R 1
Amino Acid Leu20-Pro365
Construction Biotinylated Recombinant Human Interleukin-6 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Leu20-Pro365 is expressed with a Avi, 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 65-85 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

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Keywords

IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated IL-6R-α IL-6R-alpha Interleukin-6 receptor subunit alpha Interleukin-6 receptor subunit α IL-6R subunit α Membrane glycoprotein 80 gp80 CD-126 CD 126 CD126 IL-6R subunit alpha IL-6R 1 recombinant recombinant-proteins proteins protein

 

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