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IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated
(Synonyms: Membrane glycoprotein 80, Interleukin-6 receptor subunit α, Interleukin-6 receptor subunit alpha, IL-6R-α, IL-6R-alpha, IL-6R subunit α, IL-6R subunit alpha, IL-6R 1, gp80, CD126) Copy Product InfoSynonyms: Membrane glycoprotein 80, Interleukin-6 receptor subunit α, Interleukin-6 receptor subunit alpha, IL-6R-α, IL-6R-alpha, IL-6R subunit α, IL-6R subunit alpha, IL-6R 1, gp80, CD126
Catalog No. TMPJ-00291 Copy Product Info
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $129 | 6-8 weeks | 6-8 weeks | |
| 10 µg | $213 | 6-8 weeks | 6-8 weeks | |
| 20 µg | $355 | 6-8 weeks | 6-8 weeks | |
| 50 µg | $625 | 6-8 weeks | 6-8 weeks | |
| 100 µg | $963 | 6-8 weeks | 6-8 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-Avi-6xHis |
| Accession Number | P08887 |
| Amino Acid | Leu20-Pro365 |
| Construction | Leu20-Pro365 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | Membrane glycoprotein 80, Interleukin-6 receptor subunit α, Interleukin-6 receptor subunit alpha, IL-6R-α, IL-6R-alpha, IL-6R subunit α, IL-6R subunit alpha, IL-6R 1, gp80, CD126 |
| Research Background | Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. |
| Molecular Weight | 65-85 KDa (reducing condition) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated chemical structure | IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated molecular weight
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