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PF-03635659
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Catalog No. T33941Cas No. 931409-24-4
Alias PF03635659, PF 03635659
PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD).
PF-03635659
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Purity: 99.85%
Catalog No. T33941Alias PF03635659, PF 03635659Cas No. 931409-24-4
PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $240 | In Stock | In Stock | |
| 5 mg | $590 | In Stock | In Stock | |
| 10 mg | $843 | In Stock | In Stock | |
| 25 mg | $1,280 | In Stock | In Stock | |
| 50 mg | $1,730 | In Stock | In Stock | |
| 100 mg | $2,330 | - | In Stock | |
| 500 mg | $4,670 | 6-8weeks | 6-8weeks | |
| 1 mL x 10 mM (in DMSO) | $673 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.85%
Appearance:Solid
Color:White
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Product Introduction
PF-03635659 AI Summary
PF-03635659 exhibits a range of bioactivities, mainly as an antagonist at the human recombinant M3 receptor. It inhibits carbamoyl choline-induced calcium currents and displaces [3H]-NMS. The compound has shown efficacy in several models, including CHO cells, Dunkin-Hartley guinea pig tracheal strips, human bronchial rings, and Beagle dogs. In terms of bronchodilator activity, PF-03635659 reduces lung resistance induced by acetylcholine and methacholine. Additionally, it demonstrates metabolic stability in human hepatocytes and significant unbound clearance in intravenously dosed rats..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD). |
| Synonyms | PF03635659, PF 03635659 |
| Molecular Weight | 444.57 |
| Formula | C28H32N2O3 |
| Cas No. | 931409-24-4 |
| Smiles | C(CCC(C)(C)N1CC(OC2=CC(O)=CC=C2)C1)(C(N)=O)(C3=CC=CC=C3)C4=CC=CC=C4 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.45 mg/mL (10.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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