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TAK-071

Name: TAK-071
Brand: TargetMol
SKU: T13066
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13066Cas No. 1820812-16-5

TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).

TAK-071

🥰Excellent

Purity: 98.02%

Catalog No. T13066Cas No. 1820812-16-5

TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	-
2 mg	$54	In Stock	-
5 mg	$88	In Stock	-
10 mg	$139	In Stock	-
25 mg	$246	In Stock	-
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.02%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
Targets&IC50	M1 mAChR:520 nM (EC50)
In vivo	In rats, TAK-071(0.3 mg/kg) increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits, TAK-071(10 mg/kg) also induce diarrhea .

Chemical Properties

Molecular Weight	421.46
Formula	C₂₄H₂₄FN₃O₃
Cas No.	1820812-16-5
Smiles	Cc1c(F)c2CN([C@H]3COCC[C@@H]3O)C(=O)c2cc1Cc1ccc(cc1)-n1cccn1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 134 mg/mL (317.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3727 mL	11.8635 mL	23.7270 mL	118.6352 mL
5 mM	0.4745 mL	2.3727 mL	4.7454 mL	23.7270 mL
10 mM	0.2373 mL	1.1864 mL	2.3727 mL	11.8635 mL
20 mM	0.1186 mL	0.5932 mL	1.1864 mL	5.9318 mL
50 mM	0.0475 mL	0.2373 mL	0.4745 mL	2.3727 mL
100 mM	0.0237 mL	0.1186 mL	0.2373 mL	1.1864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc