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AGPAT4-IN-1

Catalog No. T213257 Copy Product Info
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AGPAT4-IN-1 (Compound CL26) is a covalent AGPAT4 inhibitor with an IC50 of 795 nM. It binds covalently to the Cys228 site of AGPAT4, significantly inhibiting acyltransferase activity, the conversion of LPA to PA, and the downstream mTOR/S6K pathway. AGPAT4-IN-1 enhances the sensitivity of hepatocellular carcinoma (HCC) tumors to Sorafenib and significantly induces apoptosis through synergistic effects. This compound exhibits antitumor activity and reduces tumorigenicity and stem cell characteristics in a hepatocellular carcinoma xenograft mouse model.

AGPAT4-IN-1

Copy Product Info
🥰Excellent
Catalog No. T213257

AGPAT4-IN-1 (Compound CL26) is a covalent AGPAT4 inhibitor with an IC50 of 795 nM. It binds covalently to the Cys228 site of AGPAT4, significantly inhibiting acyltransferase activity, the conversion of LPA to PA, and the downstream mTOR/S6K pathway. AGPAT4-IN-1 enhances the sensitivity of hepatocellular carcinoma (HCC) tumors to Sorafenib and significantly induces apoptosis through synergistic effects. This compound exhibits antitumor activity and reduces tumorigenicity and stem cell characteristics in a hepatocellular carcinoma xenograft mouse model.

AGPAT4-IN-1
Cas No. 2411250-59-2
Pack SizePriceUSA StockGlobal StockQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
AGPAT4-IN-1 (Compound CL26) is a covalent AGPAT4 inhibitor with an IC50 of 795 nM. It binds covalently to the Cys228 site of AGPAT4, significantly inhibiting acyltransferase activity, the conversion of LPA to PA, and the downstream mTOR/S6K pathway. AGPAT4-IN-1 enhances the sensitivity of hepatocellular carcinoma (HCC) tumors to Sorafenib and significantly induces apoptosis through synergistic effects. This compound exhibits antitumor activity and reduces tumorigenicity and stem cell characteristics in a hepatocellular carcinoma xenograft mouse model.
Chemical Properties
Molecular Weight306.76
FormulaC14H11ClN2O2S
Cas No.2411250-59-2
SmilesO=C(NCC=1OC(=CC1)C2=NC=3C=CC=CC3S2)CCl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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